35180-01-9,Some common heterocyclic compound, 35180-01-9, name is Chloromethyl isopropyl carbonate, molecular formula is C5H9ClO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred suspension of PMPA (7.26 g, 0.026 mmol) in DMF (100 mL) was added Et 3 N (10.8 mL, 0.0778 mmol) at 50 C. The reaction mixture became homogeneous and chloromethyl isopropyl carbonate (12.1 g, 0.0778 mmol) was added to the reaction mixture and stirring was continued at 50 C. (oil bath temperature) for 20 h. The solvent was removed under reduced pressure and the crude product was chromatographed on a silica gel column. Elution with 10% isopropanol in CH 2 Cl 2 removed all nonpolar impurities. Further elution with the same solvent mixture yielded 1.3 g (about 10%) of the prodrug.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 35180-01-9, its application will become more common.
Reference:
Patent; GILEAD SCIENCES INCORPORATED; ARIMILLI, MURTY N; CUNDY, KENNETH C; DOUGHERTY, JOSEPH P; KIM, CHOUNG U; OLIYAI, REZA; STELLA, VALENTINO J; (59 pag.)JP2015/164934; (2015); A;,
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