Synthetic Route of 54535-22-7,Some common heterocyclic compound, 54535-22-7, name is Diethyl 2-((phenylamino)methylene)malonate, molecular formula is C14H17NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step B: Diethyl N-methyl-N-phenylaminomethylenemalonate To 10 mmol of the compound obtained in the previous Step, dissolved in tetrahydrofuran, there are added, slowly (in small portions) and under an inert atmosphere, 12 mmol of 95% NaH and then, dropwise, 30 mmol of iodomethane. The reaction mixture is then stirred, at ambient temperature and under an inert atmosphere, for 12 hours. 1 mL of methanol is added in order to neutralise the excess of sodium hydride. The solution is then concentrated in vacuo, and then water is added to the residual oil obtained. After extraction with dichloromethane, the combined organic phases are dried, filtered and concentrated under reduced pressure to yield the expected product in the form of a colourless oil. MS (EI, m/z): 276 (M+).
The synthetic route of 54535-22-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Brion, Jean-Daniel; Israel, Lucien; Le Ridant, Alain; Harpey, Catherine; Rabhi, Cherif; Kaloun, El Bachir; US2006/63801; (2006); A1;,
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