In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 394-35-4, name is Methyl 2-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 394-35-4
A mixture of 20.0 g of methyl 2-fluorobenzoate, 15.2 g of methyl thioglycolate, 21.8 g of potassium carbonate,and 150 ml of N,N-dimethylformamide was stirred for 4 hours at 60°C. After the reaction mixture was cooled to roomtemperature, water was added thereto, and the residue was washed three times with tert-butyl methyl ether. Concentratedhydrochloric acid was added to the aqueous layer, and then extraction was performed three times by using tert-butylmethyl ether. The collected organic layer was washed with water and saturated saline, dried over magnesium sulfate,and then concentrated under reduced pressure. The residues were recrystallized from ethanol and water, therebyobtaining 3.89 g of methyl 3-hydroxybenzo[b]thiophene-2-carboxylate.
The synthetic route of 394-35-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sumitomo Chemical Company Limited; MUKUMOTO, Fujio; TAMAKI, Hiroaki; KUSAKA, Shintaro; IWAKOSHI, Mitsuhiko; EP2926660; (2015); A1;,
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