Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 344-14-9, name is Dimethyl 2-fluoromalonate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H7FO4
2-Hydroxy-3-fluoro-8,8-dimethyl-6,7,8,9-tetrahydro-4H-pyrimido[1 ,2- a]pyrimidin-4-one can be prepared in the following way. A suspension of 5 g of 4,4-dimethyl-1 ,4,5,6-tetrahydropyrimidin-2- amine, 29 g of dimethyl fluoromalonate and 3.9 g of sodium methoxide is heated at 100C for 3 hours. The reaction medium is concentrated to dryness under reduced pressure. The residue obtained is taken up with ethyl ether. The solid formed is filtered off and then dried. 10 ml of water are added to the solid obtained, and the resulting mixture is cooled on ice, before acidification to pH 5-6 by adding concentrated hydrochloric acid (25%). The suspension is filtered and then the solid is washed with 5 ml of water and then dried under vacuum over P2O5, so as to give 3.15 g of 2-Hydroxy-3-fluoro-8,8-dimethyl- 6,7,8,9-tetrahydro-4H-pyrimido[1 ,2-a]pyrimidin-4-one, in the form of a yellow powder, the characteristics of which are the following: Mass spectrum (method A) (ES+/-) [M+H]+: m/z 232; [M-H]-: m/z 230; Tr (min) = 0.86
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 344-14-9.
Reference:
Patent; SANOFI; EL-AHMAD, Youssef; FILOCHE-ROMME, Bruno; LETALLEC, Jean-Philippe; MARCINIAK, Gilbert; RONAN, Baptiste; VIVET, Bertrand; WO2013/190510; (2013); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics