Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 89-91-8, name is Methyl 2,2-dimethoxyacetate, A new synthetic method of this compound is introduced below., Formula: C5H10O4
Preparation of substituted 3-hydroxy isoquinolines were carried out in the manner described in Fukumi, H.; Kurihara, H.; Heterocycles., 1978, 9(9), 1197-1205. Thus, a mixture of 4-methyl benzylamine (5.54 g, 45.7 mmol) and methyl dimethoxyacetate (6.17 mL, 50.3 mmol) was heated to 130 C. where it stirred for 4 h. After this time, the volatiles were removed under reduced pressure to provide a residue. The residue was azeotroped to dryness from toluene to provide the product, which was used directly in the next step without further purification. MS (E+) m/z: 224 (MH+); LC retention time (Method A): 2.49 min.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Weinstein, David S.; Gilmore, John L.; Sheppeck, James; Yang, Bingwei Vera; Kim, Soong-Hoon; Vaccaro, Wayne; US2005/187242; (2005); A1;,
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