Reference of 64113-91-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 64113-91-3 as follows.
A solution of 3- (3-PHENYL-1, 2, 4-oxadiazol-5-yl) propanoic acid (0. 1G, 0. 46MMOL) in DICHLOROMETHANE (10ML) was treated with 1, 1-dimethylethyl 2-aminobenzoate (0.089g, 0. 46MMOL), 1- (3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE HYDROCHLORIDE (0.097g, 0. 51MMOL) and 1H-1, 2, 3-BENZOTRIAZOL-1-OL (0.075g, 0. 56MMOL). After 4 days the reaction mixture was evaporated to dryness and the residue treated with a solution of TRIFLUOROACETIC acid (1ML) in DICHLOROMETHANE (1ML). After 2 hours the mixture was evaporated to dryness and the residue dissolved in 1ml of DMSO and subjected to purification using mass-directed HPLC. The title compound, which crystallized as a white solid from the eluant upon standing for 2 days, was filtered and dried to give 0.024g (15%) of the title compound. NMR. 5H (400MHZ, D6-DMSO) ; 3.05 (t, 2H, J=7.0 Hz), 3.32 (t, 2H, J=6.8 Hz, (partially obscured by water), 7.15 (t, 1 H, J=7.5 Hz), 7.56 (m, 4H), 7.98 (m, 3H), 8.41 (d, 1 H, J=8.3 Hz), 11. 27 (s, 1 H), 13.67 (s, 1 H) ; m/z 338 [MH+].
According to the analysis of related databases, 64113-91-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2005/16870; (2005); A1;,
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