Synthetic Route of 849758-12-9, A common heterocyclic compound, 849758-12-9, name is Methyl 4-bromo-3-fluorobenzoate, molecular formula is C8H6BrFO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 4-Bromo-3-fluorobenzoic acid methyl ester (700mg; 2. 45MMOL) was dissolved in acetonitrile (3. 0ML) and placed into a 2ml microwave vessel. To the solution was added 1.5 eq OF BIS (PINACOLATO) diboron (3. 67mmol ; 1. 08G). The mixture was stirred on a magnetic stir plate until dissolution. To the mixture was added KOAC (7. 33mmol ; 7. 16MG) and 60MG of [1,1′-Bis (DIPHENYLPHOSPHINO) FERROCENE] DICHLOROPALLADIUM (II) (0. 03MOL%). The reaction mixture was heated at 160C for 2 X 600S. AFTER completion (monitored by LC- MS), the acetonitrile was evaporated to give A black solid. The solid was dissolved in EtOAc and washed with water, brine and dried over MgSO4. After filtration, the solvent was evaporated under vacuum. The solid material was then dissolved in chloroform and filtered through silica. The chloroform was evaporated to give A dark green solid (used as crude for the next reaction).
The synthetic route of 849758-12-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RENOVIS, INC.; WO2005/32493; (2005); A2;,
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