3196-23-4, name is Methyl 1-bromocyclohexanecarboxylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C8H13BrO2
To a suspension of chromium (II) chloride (1. 00 g, 8. 10 MMOL) and lithium iodide (0. 087 G, 0. 648 MMOL) in tetrahydrofuran (20 mL) was added 4- [2- (5-METHYL-2- phenyl-1, 3-oxazol-4-yl) ethoxy] BENZALDEHYDE (Preparation 1) (1. 00 g, 3. 24 MMOL) and methyl 1-bromocyclohexanoate (1. 07 g, 4. 85 MMOL). The resulting mixture was heated at 50 C until TLC analysis indicated the reaction was complete. The mixture was cooled to ambient temperature and satuarted aqueous sodium chloride (15 mL) was added. The resulting mixture was stirred for 15 minutes, then partitioned between water and ethyl acetate. The organic phase was washed with water and dried (anhydrous magnesium sulfate), filtered and evaporated. The residue was purified by flash column chromatography (hexanes to 50% ethyl acetate/hexanes) to yield the title compound as a colorless oil (0. 797 G, 55%). LRMS (M/Z) : 450 (M+H).
The synthetic route of 3196-23-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; WO2004/92145; (2004); A1;,
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