Related Products of 106896-49-5, The chemical industry reduces the impact on the environment during synthesis 106896-49-5, name is Methyl 4-amino-3-bromobenzoate, I believe this compound will play a more active role in future production and life.
To a 1L rmmd-boitom t1ask purged with and rnaintained under an inert atrnosphere of.5 nitrogen vvas added methyl 4-amino-3-bromobenzoate 249a (13.6 g, 59.12 mmol, 1.00equiv.), (furan-3-yl)boronic acid (10 g, 89.37 mmol, 1.50 equiv.), 1,4-dioxane (500 mL), 1Maq. NaHC01 (17.5 g, 3.50 equiv.), and tetrakis(triphenylphosphine) palladium (6.86 g, 5.94mmol, 0.10 equiv.). The resulting mixture was heated at ll (J”C overnight vvith stirring. Aftercooling to room temperature, the mixture was diluted with 200 mL of water, and extracted10 with ethy 1 acetate (500 mL x 2). The combined orga.nic extracts were washed successivelywith t-hO (500 mL) and brine (500 mL x 2), dried over anhydrous sodium sulfate, andconcentrated under vacuum The crude product was purified by Flash-Prep-HPLC using thefollowing conditions (lntelFlash-1 ): Colunm, silica gel; mobile phase: EA: PE=O: 100increasing toEA: PE'”50:50 within 20 min; Detector, UV 254 nm. Removal of sol vents gavel 5 methyl 4-amino-3-(furan-3-yl)benzoate 25 l a (8.345 g, 65%) as a yellow oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 4-amino-3-bromobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARDELYX, INC.; CHAO, Jianhua; JAIN, Rakesh; HU, Lily; LEWIS, Jason Gustaf; BARIBAULT, Helene; CALDWELL, Jeremy; (582 pag.)WO2018/39386; (2018); A1;,
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