105-53-3, name is Diethyl malonate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 105-53-3
The compound 1,1,1-triethoxyethane (62.6 mL, 341 mmol),Compound diethyl malonate (224.4 mL, 990.1 mmol),Acetic anhydride (1.4 mL, 10.1 mmol) and a catalytic amount of zinc chloride (0.1 g) were placed in a reaction flask and heated to 170 C for 5.0 h.Evaporating unreacted diethyl malonate under reduced pressure,The residue was purified by column (eluent: PE/EtOAc (v/v) = 20/1).40.0 g of yellow oil were obtained.The yield was 69.8%.
The synthetic route of 105-53-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ruyuan Yong Xing Technology Services Co., Ltd.; Liu Bing; Liu Jinlei; Zhang Yingjun; Zhang Jiancun; (158 pag.)CN104744446; (2019); B;,
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