In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 42726-73-8 as follows. Recommanded Product: tert-Butyl methyl malonate
Example 143B 1-tert-butyl 3-methyl 2-(6-ethoxy-5-nitropyridin-2-yl)malonate To a solution of Example 143A, 6-chloro-2-ethoxy-3-nitropyridine (3 g, 14.81 mmol), in N,N-dimethylformamide (30 mL) at 0° C. was added sodium hydride (1.185 g, 29.6 mmol), and the mixture was stirred for 20 minutes. Then, tert-butyl methyl malonate (3.16 mL, 17.77 mmol) was added dropwise, and the mixture was stirred at ambient temperature for 2 hours. The mixture was diluted with ether and quenched with H2O. The mixture was partitioned. The organic layer was washed with brine, dried (MgSO4), filtered and concentrated under reduced pressure. The resulting residue was chromatographed on silica gel eluting with 0-20percent ethyl acetate/heptanes to provide the titled compound.
According to the analysis of related databases, 42726-73-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AbbVie Inc.; Altenbach, Robert J.; Liu, Huaqing; Clapham, Bruce; Aguirre, Ana L.; Cowart, Marlon; Koenig, John R.; Sarris, Kathy; Scanio, Marc J.; Swinger, Kerren K.; Vasudevan, Anil; Villamil, Clara I.; Woller, Kevin R.; (95 pag.)US9777020; (2017); B2;,
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