Electric Literature of 5445-17-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5445-17-0, name is Methyl 2-bromopropanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
methanol (10 mL) was added to a 100 mL flask containing magnetite, and aniline (1.82 mL, 20 mmol), sodium acetate (1.8 g, 22 mmol) and methyl 2-bromopropionate (2.45 mL) were added successively under stirring., 22 mmol), refluxed at 80C for 18 hours.After completion of the reaction, 100g to 200 mesh silica gel 1g was added to the mixture, the solvent was evaporated under reduced pressure, and the residue was separated by silica gel column chromatography (n-hexane/ethyl acetate 50 to 30:1) to give 3.5 g of a colorless oily intermediate.The yield is 98%;
The synthetic route of Methyl 2-bromopropanoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Henan University; Jiang Zhiyong; Shao Tianju; Zhao Xiaowei; Liu Yang; Qiao Baokun; (9 pag.)CN108017580; (2018); A;,
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