Synthetic Route of 4630-80-2, The chemical industry reduces the impact on the environment during synthesis 4630-80-2, name is Methyl cyclopentanecarboxylate, I believe this compound will play a more active role in future production and life.
To LDA (17.03 ml, 17.03 mmol) (1M in THF) at 0 oc was addedmethyl cyclopentanecarboxylate (1.75 g, 13.6 mmol) and the mixture stirred for 5 min. Asolution of 4-(bromomethyl)-1-chloro-2-(3-methoxypropoxy)benzene (2 g, 6.8 mmol) in THF(5ml) was added dropwise then the mixture was allow to warm toRT. The mixture wasquenched with ice and NH4CI (aq), and then extracted with EtOAc. The organics werecombined, dried (brine, Na2S04), and concentrated to an oil. The oil was purified on silicagel hex:EtOAc (eluting at -1 0%) to give methyl 1-(4-chloro-3-(3- methoxypropoxy)benzyl)cyclopentane-1-carboxylate (2.28 g, 6.69 mmol, 98% yield) as ayellow oil. LCMS (ESI) (m/z): 363.3 (M+23t.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl cyclopentanecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CATALANO, John G.; DICKSON, Hamilton D.; KAZMIERSKI, Wieslaw Mieczyslaw; LEIVERS, Martin R.; WEATHERHEAD, John Gordon; (389 pag.)WO2018/154466; (2018); A1;,
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