Application of 14273-90-6,Some common heterocyclic compound, 14273-90-6, name is Methyl 6-bromohexanoate, molecular formula is C7H13BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Typical procedure: Under a dry argon atmosphere, a solution of imidazole (Im, 2.05g, 30.1mmol) in dry THF (10mL) was added dropwise to stirred potassium tert-butoxide (3.36g, 29.9mmol) in dry THF (40mL) at 0C. The resulting reaction mixture was stirred for 2h, a solution of 5a (5.46g, 30.2mmol) in dry THF (10mL) was added dropwise. After refluxing the resulting mixture for 16h, it was cooled to room temperature and filtered. The filtrate was concentrated under reduced pressure. After dissolving the residual liquid in dichloromethane, this solution was washed with water and brine several times, dried over anhydrous sodium sulfate, and filtered. The filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography eluted with a mixed solvent of chloroform/methanol (10/1v/v). The fraction with an Rf value of 0.45 was collected and dried under reduced pressure to afford 1-[3-(methoxycarbonyl)propyl]imidazole
The synthetic route of 14273-90-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ichikawa, Tsukasa; Wako, Tsuyoshi; Nemoto, Nobukatsu; Reactive and functional polymers; vol. 99; (2016); p. 1 – 8;,
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