In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5335-05-7 as follows. category: esters-buliding-blocks
Under nitrogen protection,The racemic mixture of 3- (indol-3-yl) -butyric acid or S-3-iv)(0 · 20 g, 1 mmol)And triethylamine (0 · 10 g, 1 mmol)Dissolved in DMF solution (6ml) solution at room temperature for 5min,Then methyl chlorobenzoate (0.17 g, 1 mmol),The reaction at room temperature 24h, after the reaction was added ethyl acetate 50ml,The ethyl acetate layer was washed with water (80 ml X 3) and the ethyl acetate layer was dried over anhydrous Na 2 SO 4. After the solvent was removed by column chromatography, the target compound 3- (3-indol-3-yl) Methyl ester (0.23 g, 70%),Which is a racemic mixture or (S) isomer.
According to the analysis of related databases, 5335-05-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Bio-technology Institute; Liu Zongying; Li Zhuorong; Jin Jie; Zhu Juntai; (111 pag.)CN103664996; (2017); B;,
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