Application of 426-65-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 426-65-3 as follows.
4,4,5,5,5-pentafluoro-1-phenylpentane-1,3-dione, lithium enolate salt (Scheme 1, formula 3; X=F) A solution of lithium hexamethyldisilazide in THF (1.0 M, 7.6 mL, 7.6 mmol, 1.0 eq.) was added to dry Et2O (12 mL) and cooled to -78 C. To the cooled solution was added a solution of acetophenone (0.90 g, 7.6 mmol) in Et2O (8 mL), dropwise over 15 minutes. The mixture was stirred at -78 C. for 30 minutes, then a solution of ethyl 2,2,3,3-3-pentafluoropropionate (1.26 mL, 7.95 mmol, 1.05 eq.) in Et2O (6 mL) was added in one portion. The dry ice bath was removed, and the reaction was stirred, warming to room temperature, for 1 hour. The reaction was then evaporated to yield a tacky solid which was triturated with hexane repeatedly to yield 2.04 g (99%) of 3 as a pink solid: Rf 0.38 (50% EtOA/hexanes): 1H NMR (DMSO-d6) S 7.96 (d, 2H), 7.64 (t, 1H), 7.52 (dt, 2H), 6.64 (s, 1H).
According to the analysis of related databases, 426-65-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MICROBIOTIX, INC.; Basu, Arnab; Mills, Debra M.; Peet, Norton P.; Williams, John D.; US9101635; (2015); B2;,
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