Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3469-00-9, name is Methyl Diphenylacetate, This compound has unique chemical properties. The synthetic route is as follows., name: Methyl Diphenylacetate
(2) Preparation of 2,2-diphenylethanol To a 500mL three-opening flask was slowly added a solution of diisobutylaluminum hydride in toluene (282mL, 1mol/L) at -30C. After stirring, to the resulting mixture was slowly added a solution of methyl 2,2-diphenylacetate (21g, 92.8mmol) in dichloromethane dropwisely. After the completion of dropwise addition, the reaction was conducted at 25 C for 12 hours. After the completion of reaction monitored by TLC, to the resulting mixture was slowly added methanol (10mL), dichloromethane (100mL) and an aqueous sodium hydroxide solution (100mL, 1mol/L) at -20C. After the completion of reaction, to the reaction solution was added dichloromethane for extraction. The organic phase was washed with water, dried over anhydrous sodium sulfate, and evaporated to remove the solvent to produce 2,2-diphenyl ethanol (17 g) in a yield of 92.4 %.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3469-00-9.
Reference:
Patent; Xuanzhu Pharma Co., Ltd.; ZHANG, Hui; FAN, Mingwei; SUN, Liang; EP2703398; (2014); A1;,
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