Synthetic Route of 69812-51-7, These common heterocyclic compound, 69812-51-7, name is Methyl 4-chlorosulfonylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 30c: Methyl 4-(N-(5-((5-tert-butyloxazol-2-yl)methylthio)thiazol-2-yl)sulfa- moyl)benzoate (Compound 1404)A mixture of 0108 (0.27 g, 1 mmol), 1403 (0.23 g, 1 mol) in pyridine (10 ml) was stirred at 0C for 3 h. Water was added to afford the crude product. The crude product was purified by flash column chromatography (EtOAc: petroleum ether = 1 : 10) to afford the pure product 1404 (0.35 g, 76 %): LCMS: 468 [M+l]+. 1H NMR (400MHz, DMSO-d6) delta 1.16 (s, 9H), 3.88 (s, 3H), 4.13 (s, 2H), 6.94 (s, IH), 7.91 (d, J= 5.1 Hz, 2H), 8.12 (d, J= 5.1 Hz, 2H), 12.06 (s, IH).
The synthetic route of 69812-51-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CURIS, INC.; WO2009/36016; (2009); A1;,
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