Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5335-05-7, name is Chloromethyl benzoate, A new synthetic method of this compound is introduced below., Product Details of 5335-05-7
Preparation of iodomethyl benzoate (6) Compound 6 was prepared by a modification of a literature procedure (Maury et al , Org. Lett. 2010, 12, 3590). Chloromethyl benzoate (2.7 g, 15.9 mmol) was dissolved in acetone (20 mL). Sodium iodide (7.1 g, 47.6 mmol) was added, and the resulting mixture was stirred for 3 hours at 45 C, diluted with acetone (100 mL), filtered in the absence of light, and evaporated under reduced pressure at < 30 C. The residue was dissolved in diethyl ether (100 mL), washed with aqueous sodium bicarbonate and aqueous sodium thiosulfate, dried over anhydrous magnesium sulfate, and evaporated under reduced pressure at < 30 C in the absence of light, yielding compound 6 as a yellow oil (3.3 g, 79%). The analytical data for compound 6 were identical to those reported in Maury el al , Org. Lett. 2010, 12, 3590. Compound 6 was used immediately in the subsequent step.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; KALA PHARMACEUTICALS, INC.; ONG, Winston Zapanta; NOWAK, Pawel Wojciech; KIM, Jinsoo; ENLOW, Elizabeth M.; BOURASSA, James; CU, Yen; POPOV, Alexey; CHEN, Hongming; WO2014/144285; (2014); A1;,
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