Application of 10203-58-4,Some common heterocyclic compound, 10203-58-4, name is Diethyl isobutylmalonate, molecular formula is C11H20O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a stirred suspension of LiAlH4 (3.5 equiv.) in dry THF (1.0mL/mmol) under nitrogen atmosphere was slowly added a solution of the corresponding diethyl alkylpropanedioate (1 equiv.) in dry THF (1.0mL/mmol) at 0C. The reaction mixture was allowed to warm to rt and was then refluxed for 48h before being cooled to 0C. The reaction was quenched by careful addition of a saturated aqueous solution of NH4Cl until neutral or acidic pH. The precipitated aluminium salts were removed by filtration through a pad of Celite and washed with diethylether or a mixture of MeOH/CH2Cl2/Et2O 1:1:1. The organic phase of the filtrate was recovered, washed with water and brine, dried over MgSO4, filtered off and concentrated under reduced pressure to afford the corresponding crude product which was pure enough to be directly used in the next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diethyl isobutylmalonate, its application will become more common.
Reference:
Article; Meguellati, Amel; Ahmed-Belkacem, Abdelhakim; Nurisso, Alessandra; Yi, Wei; Brillet, Rozenn; Berqouch, Nawel; Chavoutier, Laura; Fortune, Antoine; Pawlotsky, Jean-Michel; Boumendjel, Ahcene; Peuchmaur, Marine; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 217 – 229;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics