The synthetic route of 6627-89-0 has been constantly updated, and we look forward to future research findings.
Application of 6627-89-0, These common heterocyclic compound, 6627-89-0, name is tert-Butyl phenyl carbonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 36A; To a solution of 8.00 g (76.7 mmol) pentane-1 ,3-diamine in 150 ml anhydrous ethanol 29.0 ml (153 mmol) te/t-butyl-phenyl-carbonate are added. The mixture is heated to reflux for 4 h. After cooling to room temperature 500 ml water is added, the mixture is adjusted to pH 3 with 2M HCI and extracted two times with 500 ml DCM. The aqueous layer is separated, adjusted to pH 12 with 2M sodium hydroxide solution and extracted three times with 500 ml DCM. The organic phases are combined, dried and evaporated under reduced pressure to yield the product as an oil. The product is used for the next reaction without further purification, yield: 15.5 g (100%) LC-MS (Method 1s): RT = 0.91 min MS (ESI pos): m/z = 203 (M+H)+
The synthetic route of 6627-89-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; WO2009/92566; (2009); A1;,
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