Synthetic Route of 13195-64-7,Some common heterocyclic compound, 13195-64-7, name is Diisopropyl malonate, molecular formula is C9H16O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1) using 830 mmol of sodium hydride as a catalyst,200 mmol of diisopropyl malonate and 440 mmol of propargyl bromide were added to 210 mL of anhydrous acetonitrile in an ice water bath.Stir the reaction for 8 hours.The product is washed with water,Extract with ethyl acetate and spin dry under reduced pressure.Obtaining a yellow-brown solid product,That is, compound a-1
The synthetic route of 13195-64-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anhui Normal University; Yao Liangliang; Liu Baohua; Yue Hao; Han Mengyao; Hu Yimin; (15 pag.)CN110256253; (2019); A;,
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