New downstream synthetic route of 10203-58-4

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10203-58-4.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 10203-58-4, name is Diethyl isobutylmalonate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 10203-58-4

EXAMPLE 2 Preparation of 2-ethoxycarbonyl-4-methylvaleric acid A mixture of potassium hydroxide at 85% (3.6 g; 57.34 moles), water (10 ml) and ethanol (10 ml) was heated at 70 C. and hence ethyl 2-ethoxycarbonyl-4-methylvalerate (11.75 g; 54.34 mmoles), prepared as described in example 1, was therein added. After keeping the reaction mixture at reflux temperature for 2 hours, ethanol was evaporated and the resultant solution was washed with ethyl acetate and acidified with concentrated hydrochloric acid. After extracting with ethyl acetate, drying and evaporating the solvent at reduced pressure, 2-ethoxycarbonyl-4-methylvaleric acid (6.7 g; 65.5% yield) was obtained as a colorless oil. 1 H-NMR (200 MHz, CDCl3): delta (ppm): 0.90 (d, 6H); 1.25 (t, 3H); 1.60 (m, 1H); 1.79 (t, 2H); 3.44 (t, 1H); 4.19 (g, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 10203-58-4.

Reference:
Patent; Zambon Group S.p.A.; US5739123; (1998); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics