251458-15-8, name is Methyl 2-(3-bromophenyl)-2-methylpropanoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C11H13BrO2
To a solution of ferf-butyl (4-(4,4,5,5-tetramethyl-1.3,2-dioxaborolan-2-yl)benzyl)carbamate (1.46 g, 4.40 mmol) in 1 .4-dioxane (20 mL) and water (2 mL) was added methyl 2-(3-bromo- phenyl)-2-methylpropanoate (1.13 g, 4.40 mmol), Na2C03(1.20 g, 8.80 mmol) and Pd(dppf)CI2(150 mg) and the mixture was stirred at 90C for 3 h under N2, cooled, diluted with water (40 mL) and extracted with EA (3 x 20 mL). The combined organic layer was washed with brine (30 mL), dried over Na2S04, filtered, concentrated and purified by FCC (PE:EA = 10: 1 ) to give compound 24a as a white solid.
The synthetic route of 251458-15-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHENEX-FXR GMBH; GEGE, Christian; BIRKEL, Manfred; HAMBRUCH, Eva; DEUSCHLE, Ulrich; KREMOSER, Claus; (203 pag.)WO2019/16269; (2019); A1;,
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