Synthetic Route of 4891-38-7,Some common heterocyclic compound, 4891-38-7, name is Methyl Phenylpropiolate, molecular formula is C10H8O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A mixture of N-methylprop-2-yn-1-amine (1c, 1.5 mmol, 103.6 mg), dimethyl acetylenedicarboxylate (2a, 1.0 mmol, 142.1 mg), AgOAc (16.7mg, 0.1 mmol) and DBU (15 2mg, 1.0 mmol) in DMF (7 mL) in a thick-walled screw-capped Pyrex tube was stirred with a magnetic stirrer at 80 C for 2 h. After cooling to room temperature, the reaction mixture was diluted with saturated aq. NH4Cl (10 mL) and extracted with ethyl acetate (5×10.0 mL). The combined organic phrase was washed with brine (2×15.0 mL) and dried over anhydrous Na2SO4. After removal of solvent under reduced pressure, purification was performed by flash column chromatography on silica gel with petroleum ether/ethyl acetate (7:3) as eluent to afford 4ca in 84 % yield (177. 2mg, 0.84 mmol).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl Phenylpropiolate, its application will become more common.
Reference:
Article; Nizami, Tauqir A.; Hua, Ruimao; Tetrahedron; vol. 73; 42; (2017); p. 6080 – 6084;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics