Application of 36692-49-6, A common heterocyclic compound, 36692-49-6, name is Methyl 3,4-diaminobenzoate, molecular formula is C8H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A 25 mL sealed tube equipped with a magnetic stirrer bar was charged with catalyst CoOxNC-800 (20 mg, 10 mol%) then sealed with a rubber septum and evacuated to remove air.Benzene-1,2-diamine (0.2 mmol), PhCHO (0.24 mmol), and THF(5 mL) were injected into the tube from a syringe, and the tube was placed in a preheated oil bath at 100 C for 8 h. When the reaction was complete, the mixture was filtered and the organic layers were collected, combined, dried (Na2SO4), and concentrated under vacuum. The residue was purified by passage through a column of silica gel (200-300 mesh) to give a white solid; yield: 38.1 mg (98%).
The synthetic route of 36692-49-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Wang, Zhaozhan; Song, Tao; Yang, Yong; Synlett; vol. 30; 3; (2019); p. 319 – 324;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics