Adding a certain compound to certain chemical reactions, such as: 3196-15-4, name is Methyl 2-bromobutyrate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3196-15-4, Safety of Methyl 2-bromobutyrate
To a solution of naphthalene-2,7-diol (5.0 g, 31 mmol) in acetone (200 mL) was added cesium carbonate (10.1 g, 31 mmol) at room temperature under a nitrogen atmosphere with stirring. After the addition, the mixture was stirred at room temperature for 3 min and then methyl-2-bromobutyrate (5.6 g, 31 mmol) was added. The mixture was stirred at room temperature overnight and then filtered to remove solids. The filtrate was concentrated under reduced pressure and the residue was purified by column chromatography (over silica gel with ethyl acetate and hexanes in volume ratios from 10 to 80 % as eluents) to give the title compound (3.9 g) as a solid. in NMR (CDCI3) delta 7.62-7.70 (m, 2H), 6.85-7.05 (m, 4H), 5.85 (s, 1H), 4.68-4.78 (m, 1H),3.75 (s, 3H), 2.00-2.10 (m, 2H), 1.08-1.15 (t, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-bromobutyrate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; CREWS, Alvin, Donald, Jr.; DING, Amy, X.; TSENG, Chi-Ping; WO2012/87372; (2012); A1;,
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