Synthetic Route of 135484-83-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 135484-83-2, name is Methyl 2-amino-4-bromobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Methyl 2-amino-4-bromobenzoate (15 g, 65 mmol) in trifluoroacetic acid (75 mL) and concentrated HC1 (15 mL) was cooled in an ice water bath. To it sodium nitrite (9.0 g, 130 mmol) in water (15 mL) was added via addition funnel over 15 mm. The reaction stirred at 0 C for 30 mm. Then sodium azide (13 g, 196 mmol) was slowly addedportion-wise. The reaction was stirred at 0 C to rt for 1.5 hrs. The solvents were removed and H20 and EtOAc were added. The layers were separated and the organic layer was washed with saturated NaHCO3 three times and dried over Na2SO4. The solvent was removed and the crude material was purified by chromatography thru a Si02 using a solvent gradient of 100 % Hx to 20 % EtOAc / Hx to afford the title compound (16 g, 61mmol, 95 %). ?H NMR (400 MHz, CDC13) oe ppm 7.74 (d, J 8.4 Hz, 1H), 7.38 (d, J 1.8 Hz, 1H), 7.34 – 7.29 (m, 1H), 3.90 (s, 3H).
The synthetic route of Methyl 2-amino-4-bromobenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; EXELIXIS PATENT COMPANY LLC; KICK, Ellen, K.; BODAS, Mandar; MOHAN, Raju; BUSCH, Brett, B.; AVERBUJ, Claudia; VALENTE, Meriah; WURTZ, Nicholas; RAO, Prasanna Savanor, Maddu; SHETTY, Jeevanprakash; VENU, Alla; WO2014/152738; (2014); A1;,
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