Adding a certain compound to certain chemical reactions, such as: 106614-28-2, name is Methyl 2,4-difluorobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 106614-28-2, Application In Synthesis of Methyl 2,4-difluorobenzoate
Step 2; Preparation of 2-fluoro-4-(4-metriotayl-piperazm-1-yl)-benzolc acid methyl ester and 4-fluoro-2-{4-methyl-pfpeFazin-1-yl}-benzoic acid methyl ester; A mixture of 2,4-difluoro-benzoic acid methyl ester (4 5 g, 26,2 mmol), 1-methyi- piperazine (4 36 mL, 39,2 mmol, 1.5 eq.) and K2CO3 (3,62 g, 26.2 mrno), 1 eq.) in N1N- dlmethylformamide (10 mL) was stirred at 100C for 4 hours. The mixture was then poured into 200 mL of water and extracted with 150 mL of EtOAc. The organic layer was separated, washed with water (100 mL) dried over sodium sulphate and evaporated to dryness. The crude was purified by flash chromatography on silica gel, using a mixture dichloromethane- MeOH-30% NH4OH 95:5:0 5 as eluant, affording 1 65 g of 2-fluoro-4-(4-rnethyi-piperazin-1-yl)- benzoic acid methyl ester (first eluting, pale yeilow solid) and 3.04 g of 4-fluoralpha-2-(4-methyl- piperazin-1-yl)-benzoic acid methyl ester (second eiuting, yellow oil).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,4-difluorobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PFIZER ITALIA S.R.L.; WO2007/99171; (2007); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics