Reference of 55954-23-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55954-23-9, name is Methyl 2,4-dichlorophenylacetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
[0198] To the mixture of methyl 2-(2,4-dichlorophenyl)acetate (0.5 g, 2.29 mmol) in THF (10 mL) was added NaH(0.12 g, 2.98 mmol) at oo C. portionwise, then the mixturewas stirred at 25 C. for 0.5 hr, then to the mixture was addedMel (0.42 g, 2.98 mmol) dropwise, the mixture was stirred at25 C. for 2 hrs. After the starting material was consumedcompletely detected by TLC, the mixture was quenched byH20 (lOmL), extracted withEtOAc (10mL*3). The organicswere dried over Na2S04 and concentrated in vacuum to getthe title compound (0.3 g, yield: 50.8%) as yellow oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,4-dichlorophenylacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; Hodous, Brian L.; (150 pag.)US2016/31892; (2016); A1;,
Ester – Wikipedia,
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