Reference of 1150566-27-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1150566-27-0 as follows.
(2R,4S)-4-Fluoro-2-[3-fluoro-5-(methylsulfanyl)phenyl]pyrrolidine hydrochloride (Preparation 25, 23.75 g, 89.4 mmol), KF (46.73 g, 804.3 mmol), ethyl 6- chloroimidazo[1 ,2-b]pyridazine-3-carboxylate (19.76 g, 87.6 mmol) were suspended in DMSO (350 ml). The reaction was heated at 130C for 82 h. The reaction mixture was allowed to cool to rt before being poured into distilled water (750 ml), which precipitated a beige solid. The liquid was decanted and the solid was washed with distilled water three times (3 x 250 ml). The beige solid was taken up in MTBE (500 ml) and partitioned between sat. aq. NH4CI (500 ml) and then finally brine (500 ml). The organic layer was dried (Na2S04), filtered and concentrated in vacuo to afford a dark reddish residue which was used without further purification (30.52 g, 82 %). LCMS m/z = 419 [M+H]+
According to the analysis of related databases, 1150566-27-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BENEVOLENTAI BIO LIMITED; BROWN, Alan; GLEN, Angela; (115 pag.)WO2020/39209; (2020); A1;,
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