Application of 927-68-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 927-68-4 as follows.
EXAMPLE 128a Preparation of intermediate Acetic acid 2-(2-formyl-4-methyl-phenoxy)-ethyl ester To a solution of 2-hydroxy-5-methyl-benzaldehyde (2.4 g, 18 mmol) (Aldrich) in N,N-dimethylformamide (30 mL) was added cesium carbonate (6 g, 18 mmo), potassium iodide (3 g, 18 mmol) and 2-bromoethyl acetate (7 g, 42 mmol), Aldrich). The reaction mixture was heated at 100 C. for 3 h. The mixture was cooled to room temperature and diluted with ethyl ether, washed with water, brine, separated, and concentrated. The residue was purified by chromatography (EtOAc:Hexanes=1:6) to give acetic acid 2-(2-formyl-4-methyl-phenoxy)-ethyl ester as a yellow oil (Yield 4 g, 100%).
According to the analysis of related databases, 927-68-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Chen, Li; Ding, Qingjie; Liu, Jin-Jun; Yang, Song; Zhang, Zhuming; US2007/213341; (2007); A1;,
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