Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18014-00-1, name is Dimethyl 2,5-dibromoterephthalate, A new synthetic method of this compound is introduced below., Recommanded Product: 18014-00-1
Carbazole (6.68 g, 0.04 mol),Methyl 2,5-dibromo-1,4-terephthalate (10.48 g, 0.02 mol),O-dichlorobenzene (15ml),Potassium carbonate (5.52 g, 0.04 mol),18-crown-6 (1.07g, 4mmol),Cuprous iodide (0.76g, 4mmol)Mix in a dry single-mouth bottle (50ml),Under the protection of nitrogen atmosphere,Heating to 150 C, stirring and refluxing reaction for 18h ~ 36h,After cooling, suction filtration,Washed with dichloromethane,After rotary evaporation to remove the volatile solvent in the filtrate,Separation by column chromatography,Wet loading,Using petroleum ether/ethyl acetate (6:1) as the eluent,The yellow-green solid product (7.76 g, 14.8 mmol) was obtained.The yield is 74%;
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Nanjing University of Posts and Telecommunications; Qian Yan; Wang Yingnan; Ye Jingfang; Mi Baoxiu; Gao Zhiqiang; Yi Mingdong; Zhang Guangwei; Xie Linghai; (10 pag.)CN110054581; (2019); A;,
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