Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 42122-75-8, name is Methyl 5-amino-2-chlorobenzoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H8ClNO2
37.12 g (0.2 mol) was added to a 500 mL three-necked flask as shown in formula (C)2-chloro-5-amino-benzoic acid methyl ester, 100 mL hydrochloric acid and 70 mL water,Mechanically stirred, cryogenically cooled to -5-0 C, with a pale yellow solid precipitated,Dissolve 13.8 g (0.2 mol) of sodium nitrite in 20 mL of water.Then slowly added dropwise to the above three-necked flask, after the dropwise addition within 45 minutes,The light yellow solid in the three-necked flask was completely dissolved, and the solution was orange-yellow.The temperature of the reaction solution was maintained at -2-0 C. The mixture in a three-necked flask was stirred for 15 min.Then, 45.7 g (0.25 mol HBF4) of 48% tetrafluoroboric acid solution was added dropwise.After about 30 minutes, the temperature of the reaction solution is kept at 0-2 C.Stirring was continued for 2 hours. After the reaction is completed, the reaction solution is suction filtered.The residue was washed successively with dilute tetrafluoroboric acid solution, washed with 50% ethanol (50 mL) and washed with anhydrous ethanol (50 mL), and dried to give 43.2 g of pale yellow solid, yield 75.6%.
The synthetic route of 42122-75-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Zhejiang University of Technology; Tan Chengxia; Pei Dan; Zhang Fan; Zhang Donglin; (26 pag.)CN108997325; (2018); A;,
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