Electric Literature of 394-35-4, The chemical industry reduces the impact on the environment during synthesis 394-35-4, name is Methyl 2-fluorobenzoate, I believe this compound will play a more active role in future production and life.
To methyl 2-fluorobenzoate (300 mg) in 9 mL of THF was added NaHMDS (5.2 mL, 1 M in THF) at -78°C. To this mixture was then added (4-chloro-2-fluorophenyl)acetic acid (367 mg) as solid in one portion at -78°C. The mixture was stirred at -78°C for 4 h and then quenched with 3 N HC1 at this temperature and stirred at rt for overnight. The mixture was diluted with ethyl acetate and water. The organic layer was dried and concentrated to remove solvents. The afforded residue was purified by silica gel flash chromatography (0 to 100percent EtOAc/hexane, product out at 25percent) to give the desired product 2-(4-Chloro-2-fluorophenyl)-l-(2- fluorophenyl)ethanone as white solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-fluorobenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LAN, Ping; LIU, Kun; OGAWA, Anthony; SHEN, Hong; YANG, Christine; WANG, Yuguang; BERESIS, Richard; QI, Changhe; WO2012/139495; (2012); A1;,
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