Synthetic Route of 58656-98-7, These common heterocyclic compound, 58656-98-7, name is tert-Butyl 4-fluorobenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N,N-Dimethyl-3-oxo-1,2-dihydroindazole-5-carboxamide (900 mg; 4.39 mmol; 1.00 eq.), 1-methyl-2-pyrrolidinone (5.00 mL), cesium carbonate (4.29 g; 13.16 mmol; 3.00 eq.) andtert-butyl 4-fluoro-benzoate (2.58 g; 13.2 mmol; 3.00 eq.) were stirred at 110 C for4 hours. The reaction mixture was cooled, diluted with 50 mL of ethyl acetate. The organic layer was washed with brine (20 mL), water ( 20 mL), dried over MgSO4and concentrated.tert-Butyl 4-(5-(dimethylcarbamoyl)-3-oxo-2,3-dihydro-1H-indazol-1-yl)benzoate is isolated without further purification as a beige solid (900 mg; 53.8%)1H NMR (DMSO-d6) delta: 1.58 (s, 9H), 3.01 (s, 6H), 7.58 (dd,J =8.8, 1.7 Hz, 1H), 7.90 – 7.84 (m, 3H), 7.95 (d,J =8.8 Hz, 1H), 8.08 – 8.03 (m, 2H), 11.77 (s, 1H).MS-ESIm/z382 [MH+].
Statistics shows that tert-Butyl 4-fluorobenzoate is playing an increasingly important role. we look forward to future research findings about 58656-98-7.
Reference:
Article; Ouvry, Gilles; Bouix-Peter, Claire; Ciesielski, Fabrice; Chantalat, Laurent; Christin, Olivier; Comino, Catherine; Duvert, Denis; Feret, Christophe; Harris, Craig S.; Lamy, Laurent; Luzy, Anne-Pascale; Musicki, Branislav; Orfila, Danielle; Pascau, Jonathan; Parnet, Veronique; Perrin, Agnes; Pierre, Romain; Polge, Gaelle; Raffin, Catherine; Rival, Yves; Taquet, Nathalie; Thoreau, Etienne; Hennequin, Laurent F.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 23; (2016); p. 5802 – 5808;,
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