A new synthetic route of Methyl 2-bromopropanoate

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5445-17-0, name is Methyl 2-bromopropanoate, A new synthetic method of this compound is introduced below., Computed Properties of C4H7BrO2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5445-17-0, name is Methyl 2-bromopropanoate, A new synthetic method of this compound is introduced below., Computed Properties of C4H7BrO2

To a suspension of K2CO3 (3.6 g, 26.5 mmol) and tert- butyl piperazine-1-carboxylate (1.0 g, 5.3 mmol) in CH3CN (15 mL) was added methyl 2- bromopropanoate (2.2 g, 13.4 mmol). The reaction was stirred at 80 C for 10 hours. TLC showed that the reaction was complete. The reaction mixture was allowed to cool to room temperature, then the solid filtered off and solvent removed under vacuum. The residue was purified by silica gel column chromatography (CH2Cl2/MeOH = 50:1) to give tert-butyl 4-(1-methoxy-1-oxopropan-2-yl)piperazine-1- carboxylate (2-2) as a brown oil (1.4 g, yield: 99%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KURA ONCOLOGY, INC.; THE REGENTS OF THE UNIVERSITY OF MICHIGAN; WU, Tao; LI, Liansheng; WANG, Yi; REN, Pingda; GREMBECKA, Jolanta; CIERPICKI, Tomasz; KLOSSOWSKI, Szymon; POLLOCK, Jonathan; BORKIN, Dmitry; (198 pag.)WO2017/161028; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics