Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4606-07-9, name is Ethyl cyclopropanecarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Ethyl cyclopropanecarboxylate
Example 2: Preparation of 2-bromo-1-cyclopropyl-2-(2-fluorophenyl) ethanone: Tetrahydrofuran (90 mL), magnesium turnings (4.4 g), and iodine are charged into a round bottom flask under nitrogen atmosphere at 28C. A solution of 2-bromopropane (22.07 g) in tetrahydrofuran (60 mL) is added to the reaction mass at 20C in 30 minutes and stirred at the same temperature for 1 hour. The solution of 2-(2-fluoro phenyl)acetic acid (11 g) [having less than 0.06% of 2-(3- fluorophenyl)acetic acid impurity] in tetrahydrofuran (20 mL) is added to the reaction mass at 20C in 30 minutes. The reaction mass is heated to 65C and stirred at the same temperature for 3 hours. The reaction mass is cooled to 5C. Ethyl cyciopropanecarboxylate (7.8 g) is added to the reaction mass in 10 minutes at 5C. The reaction mass is heated to 70C and stirred at the same temperature for 3 hours. The reaction mass is cooled to 20C. Water (10 mL) and 2N hydrochloric acid (90 mL) are added to the reaction mass at 20C and stirred for 20 minutes. The organic and aqueous layers are separated. The aqueous layer is extracted with dichloromethane twice (10 mL x 2). The combined organic layer is washed with saturated solution of sodium bicarbonate. The organic layer is dried over sodium sulfate. The solvent is evaporated under vacuum at 40C to get residue (6.8 g). Chloroform (130 ml) is added to the residue at 28C. N- bromo succinamide (7.8 g), azobisisobutyronitrile (0.39 g) and p-toluenesulfonic acid (0.19 g) are added to the reaction mass at 28 C. The reaction mass is heated to 65C and stirred at the same temperature for 4 hours. The reaction mass is cooled to 5C and stirred at the same temperature for 1 hour. The reaction mass is filtered at 5C to remove unwanted residue if any. The filtrate is washed with aqueous solution of sodium bisulfate (50 mL). The organic and aqueous layers are separated. The aqueous layer is extracted with chloroform (10 mL). The organic layers are combined and evaporated at 65C to get residue. Yield: 18.2 g; 2-bromo-1-cyclopropyl-2-(3-fluorophenyl)ethanone impurity. 0.051% by HPLC.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4606-07-9.
Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; ANUMULA, Raghupathi Reddy; GILLA, Goverdhan; AALLA, Sampath; METIL, Dattatray, Shamrao; KURELLA, Srinivas; CHARAGONDLA, Kavitha; WO2012/18791; (2012); A2;,
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