Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19063-55-9, name is 6-Bromochromen-2-one, A new synthetic method of this compound is introduced below., Quality Control of 6-Bromochromen-2-one
(1) Weigh 5.2 g of DL-malic acid (38.78 mmol) in a SCHLENK reaction tube.10 g of m-bromophenol (58.17 mmol) was added under N2 atmosphere.13mL of 98% concentrated sulfuric acid was added dropwise with stirring in an ice bath.The reaction was stirred at 120 C for 6 h. After the reaction, cool to room temperature.The reaction solution was slowly dropped into a stirred saturated saline solution, and filtered to give a solid.It was redissolved in dichloromethane, washed with water three times, and the organic phase was dried over anhydrous sodium sulfate.concentrate. Separated and purified by silica gel column chromatography.The mobile phase was petroleum ether/dichloromethane = 3/2. Finally, both Br-C5 and Br-C7 were obtained as white solids, respectively 1.60 g, 5.66 g.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Xi’an Jiaotong University; Zhou Guijiang; Feng Zhao; Yang Xiaolong; (40 pag.)CN109608502; (2019); A;,
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