These common heterocyclic compound, 14064-10-9, name is Diethyl 2-chloromalonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 14064-10-9
General procedure: A mixture of diethyl chloromalonate (19.1 mmol) and suitable sodium phenate (20.1 mmol), prepared from an equivalent amount of the corresponding phenol and sodium in abs EtOH, was stirred and heated under reflux in acetone (100 mL) for 4 h. The solvent was removed under reduced pressure, the residue was taken up with water and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over Na2SO4 and concentrated to give an oily residue which was chromatographed on silica gel column (petroleum ether/ethyl acetate 9:1 as eluent). The desired compounds were obtained as pale yellow oils in 14-77percent yield.
The synthetic route of Diethyl 2-chloromalonate has been constantly updated, and we look forward to future research findings.
Reference:
Article; Fracchiolla, Giuseppe; Laghezza, Antonio; Piemontese, Luca; Parente, Mariagiovanna; Lavecchia, Antonio; Pochetti, Giorgio; Montanari, Roberta; Giovanni, Carmen Di; Carbonara, Giuseppe; Tortorella, Paolo; Novellino, Ettore; Loiodice, Fulvio; Bioorganic and Medicinal Chemistry; vol. 20; 6; (2012); p. 2141 – 2151;,
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