Application of 140-11-4, These common heterocyclic compound, 140-11-4, name is Benzyl acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 5 ml glass bottle into which the magnet was placed,Then add NaOEt (17 mg, 0.25 mmol),The catalyst E (0.38 mg, OOl mmol),Benzyl acetate (0. 7508 g, 5 mmol, S / C = 10000: 1),Solvent dioxane (2.5 mL),The above reaction system was placed in a high-pressure reactor, Replacement of hydrogen three times,Charged with hydrogen gas of 50 atm,The reaction vessel was placed in a 80 C oil bath,Heating and stirring 16h,The reaction vessel was cooled in an ice bath.The reaction system was analyzed by gas chromatography (SPBTM-5, FUSEDSILICA Capillary Column, 30mX0.25mmX0.25ym, filmthickness)Injection temperature of 250 C,Detection temperature 260 C, program temperature 120 C (0 C) -20 C / min to 240 C (Omin). Gas chromatographic analysis yielded 82%.
The synthetic route of 140-11-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; WUHAN KAITE LISI TECHNOLOGY CO LTD; Zhang, Xumu; Tan, xuefeng; (15 pag.)CN104387418; (2016); B;,
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