Adding a certain compound to certain chemical reactions, such as: 26218-04-2, name is 2-Ethylhexyl 4-aminobenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26218-04-2, name: 2-Ethylhexyl 4-aminobenzoate
200 mL of toluene was added to the flask, the water was refluxed for 1.0 hour,Cooled to about 80 ,Into the intermediate III79.30g (0.20mol);The intermediate II 104.58g (0.42mol), 200mL toluene was placed in a beaker and stirred until fully soluble constant pressure dropping funnel; when the temperature reached 80 ,A solution of isooctyl p-aminobenzoate in toluene, the reaction 7-8h. Add water and separate the organic phase.The organic phase was distilled under atmospheric pressure to obtain crude toluene, suction filtered;The crude product was added 950g ethanol heated to full solubility,Then add 10g of activated carbon and 10g clay reflux bleaching 1h,The octyl triazone was filtered off with suction, white solid with HPLC purity of 99.45% and yield of 88.1%.
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Reference:
Patent; China Three Gorges University; Li Dejiang; Liu Yiwen; Xie Yibi; (7 pag.)CN104860893; (2017); B;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics