Synthetic Route of 711-01-3,Some common heterocyclic compound, 711-01-3, name is Methyl adamantane-1-carboxylate, molecular formula is C12H18O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A flame-dried round bottom flaskcharged with 40 mmol (4.0 equiv) of 4-bromoanisole in 40 mL THF was cooled to?78 °C and 16 mL BuLi (2.5 M in hexane, 40 mmol, 4.0 equiv) was added dropwisevia syringe. The mixture was stirred for 1.5 h at ?78 °C before the addition of thecorresponding methyl ester (10 mmol, 1.0 equiv), then the mixture was warmed toroom temperature and stirred overnight. After ammonium chloride solutionquenching, the precipitated solid was removed by filtration. The filtrate was extractedwith ethyl acetate (3 × 30 mL), washed with sodium chloride solution, and dried overNa2SO4. After filtration and concentration, the residue was purified by columnchromatography to afford the tertiary alcohol as a white solid.
The synthetic route of 711-01-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Pan, Yue; Jia, Kunfang; Chen, Yali; Chen, Yiyun; Beilstein Journal of Organic Chemistry; vol. 14; (2018); p. 1215 – 1221;,
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