Synthetic Route of 50893-36-2, The chemical industry reduces the impact on the environment during synthesis 50893-36-2, name is 1-Chloroethyl ethyl carbonate, I believe this compound will play a more active role in future production and life.
EXAMPLE 119B 1-(Ethyloxycarbonyloxy)ethyl 4-{N-butyl-N-[(2′-[N-triphenylmethyl-1H-tetrazol-5-yl]biphenyl-4-yl)methyl]amino}pyrimidine-5-carboxylate The compound resulting from Example 119A (1.00 g, 1.5 mmol) was dissolved in anhydrous dimethylformamide (3 mL) and potassium carbonate (616 mg, 4.5 mmol), 1-chloroethyl ethyl carbonate (460 mg, 3 mmol), sodium iodide (450 mg) and triethylamine (5 drops) were added. After stirring at ambient temperature for 30 hours, the reaction mixture was poured into saturated aqueous ammonium chloride and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over sodium sulfate and sodium carbonate, and concentrated under reduced pressure. Chromatography eluding with ethyl acetate/hexane mixtures provided the title compound as an amorphous solid (470 mg, 40percent).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Chloroethyl ethyl carbonate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Abbott Laboratories; US5250548; (1993); A;,
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