2905-69-3, name is Methyl 2,5-dichlorobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 2905-69-3
General procedure: The following procedure is representative of these reactions. PhSH (5 mmol) and t-BuOK (5.1 mmol) were added to 250 mL of distilled liquid ammonia; PhS- ions were ready for use. The substrate, methyl 2,5-dichlorobenzoate (1 mmol), was added to the solution, and the reaction mixture was irradiated for 2 h. The reaction was then quenched with an excess of ammonium nitrate (or methyl iodide), and the ammonia was allowed to evaporate. The solid was dissolved in water, and HNO3 was added to the water phase to reach pH=3 before extraction with diethyl ether. Products were isolated by column chromatography employing silica gel and quantified by GC using the internal standard method.
The synthetic route of 2905-69-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Uranga, Jorge G.; Montanez, Juan P.; Santiago, Ana N.; Tetrahedron; vol. 68; 2; (2012); p. 584 – 589;,
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