19064-14-3, name is Ethyl 2,6-difluorobenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 19064-14-3
D. Ethyl 2-fluoro-6-[3,4-(methylene)dioxyphenoxy]benzoate Ethyl 2,6-difluorobenzoate (558 mg, 3.0 mmol) was added to dry sodium 3,4-methylenedioxyphenoxide (3.0 mmol, prepared as described in part A) in DMSO followed by addition of dry DMSO (2 ml). The reaction mixture was warmed to 50 C. forming a solution which turned from brown to green upon further heating. After 90 min., the reaction was cooled to 25 C., diluted with water (10 ml) and extracted with EtOAc (3*10 ml). The organic extract was washed with water (2*7 ml) and brine (7 ml), dried (MgSO4) and concentrated to give a light yellow oil. The product was purified by flash chromatography on SiO2 (5-20% EtOAc/hexane) yielding 532 mg of ethyl 2-fluoro-6-[3,4-(methylenedioxy)phenoxy]benzoate as a colorless oil (58% yield).
The synthetic route of 19064-14-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Texas Biotechnology Corporation; US5977117; (1999); A;,
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