A common compound: 61644-18-6, name is Chloromethyl isobutyrate, belongs to esters-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 61644-18-6
At room temperature,N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)-propane-1-sulfonamide (0.1g, 0.2mmol)And triethylamine (57 muL, 0.40 mmol) was dissolved in DMF (1 mL).And add to it Chloromethyl isobutyrate(34 mg, 0.25 mmol).The reaction mixture was stirred at room temperature for 16 hr and then evaporated.The residue was purified by silica gel column chromatography ( petroleum ether / ethyl acetate (v/v) = 4/1 to 3/1).The title compound was obtained as a white solid (45 mg,37.5%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 61644-18-6, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Wang Tingjin; Tang Yin; Sun Mingming; Wang Qian; (74 pag.)CN103626765; (2016); B;,
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