Application of 69812-51-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69812-51-7, name is Methyl 4-chlorosulfonylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.
Preparation 102; 4-(3-Cyclopentyl-indazole-1-sulfonyl)-benzoic acid methyl ester; Combine 3-Cyclopentyl-lH-indazole (2.168 g 11.640 mmole) with triethylamine (3.526g, 34.92 mmoles) in 50 mls of dichloromethane. Dissolve 4- Chlorosulfonyl-benzoic acid methyl ester (4.085g, 17. 460mmole) in dichloromethane 50ml and add drop wise to solution at 0 C. Stir the reaction is for 12 hrs. Dilute the reaction and wash with NaHC03. Dry organic layer over MgS04 and concentrate. Purify the residue via column chromatography with a mixture of ethyl acetate and hexanes to isolate 2.046g (Yield=48. 5%) of the title compound: MS ES+385.3.
The chemical industry reduces the impact on the environment during synthesis Methyl 4-chlorosulfonylbenzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ELI LILLY AND COMPANY; WO2005/66126; (2005); A1;,
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