In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2216-92-4 as follows. SDS of cas: 2216-92-4
N-phenylglycine ethyl ester (781 mg, 4.3 [MMOL),] 4-chlorobenzyl chloride (690 mg, 4.3 [MMOL)] and sodium iodide (64 mg) were dissolved in toluene (7 mL) under argon. The reaction was heated in a graphite bath at 80 [C] for 24 h. After cooling to room temperature, the reaction was diluted with ethyl acetate and washed with [1 M HCI FOLLOWED] by brine. The solution was dried over MgS04, filtered, and concentrated in vacuo. Purification of the resultant oil by flash chromatography (10: 1 hexanes/EtOAc) afforded the title compound as a green oil (669 mg, 51 %). MS (ES+) [M/Z 304 (MH+).]
According to the analysis of related databases, 2216-92-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
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