Synthetic Route of 609-12-1,Some common heterocyclic compound, 609-12-1, name is Ethyl 2-bromo-3-methylbutanoate, molecular formula is C7H13BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
in room temperature,2-(2-Methyl-1,3-dioxolan-2-yl)ethan-1-amine (Compound 2) (28.86 g, 220 mmol) was first dissolved in acetonitrile.The above solution was then added to 3-bromo-4-ethoxy-4-methyl-4-oxobutan-1-yl hydrazone with stirring.(Compound 1) (41.61 g, 200 mmol) and triethylamine (42 mL, 302 mmol) EtOAc.The resulting mixture was stirred at room temperature overnight.Pour into 500 mL of ether.The resulting suspension was extracted with 300 mL of water.It was extracted twice with 300 mL of 2 mol/L hydrochloric acid.The combined extracts were basified by the addition of a 25% aqueous sodium hydroxide solution and extracted twice with 500 mL x 2 ethyl acetate.The extracts were combined and washed successively with water and saturated brine.It was dried over anhydrous magnesium sulfate. After removing the desiccant by filtration,Solvent volatilization,45.54 g of yellow (2-(2-methyl-1,3-dioxolan-2-yl)ethyl)proline ethyl ester were obtained(Compound 3),The yield was 87.8%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 2-bromo-3-methylbutanoate, its application will become more common.
Reference:
Patent; Li Huaxu; (9 pag.)CN108164517; (2018); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics